- Düzenleme Hizmetlerimiz
- Çeviri
- Konu Alanları
- Editörlerimiz
- Yayın Destek Hizmetleri
- Kalite Sistemi
- Ücretlerimiz
- SSS
- Kullanıcı Girişi
Hırıltı ve nefes darlığı bronşiyal astımın ana semptomlarıdır. Astımlı hastalarda, her ikisi de artmış oksidatif strese işaret eden, lökositlerden artmış süperoksit üretimi ve artmış lipid peroksidasyon ürünleri görülür. Askorbik asit, serbest radikalleri doğrudan nötralize eden önemli bir antioksidandır ve bu nedenle astımlı hastaların akciğerlerinde redoks durumunu sürdürmek için sürekli olarak kullanılır. Hatch ve ark. askorbik asitin akciğer solunum yollarının yüzey astarında bulunan önemli bir antioksidan olduğunu ve endojen ve eksojen oksidanlara karşı koruma sağladığını öne sürmüştür. Hırıltı olan çocuklarda bulduğumuz düşük askorbik asit seviyesi askorbik asitin, normal fizyolojik işlevi ile ve sürekli oksidan radikal oluşumunun önüne geçmek ve eksojen oksidanları nötralize etmek için artan kullanımı ile bağlantılı olabilir. Dolayısıyla askorbik asit eksikliği, astım patofizyolojisinin altında yatan bir faktör veya solunum yolu inflamasyonuna bir yanıt olabilir. Hırıltılı çocuklardaki düşük askorbik asit düzeylerine ilişkin bulgularımız araştırmacıların düşük askorbik asit düzeylerini, askorbik asitin vücudun savunma mekanizmasının ve dokuların bütünlüğünün, yenilenme ve iyileşme süreçlerinin sürdürülmesinde oynadığı roller dahil olmak üzere normal fizyolojik işlevlerine bağladığı önceki çalışma bulgularıyla uyumludur. Soğuk algınlığı sırasında solunum mukozasının tahrip olması ve buna bağlı olarak doku askorbik asit seviyesinin düşmesi mukoza yüzeyinin iyileşmesini geciktirerek daha uzun süreli astım semptomları ortaya çıkarabilir. Bir çalışmada astımlı hastalarda hastalığın asemptomatik dönemlerinde bile antioksidan vitaminlerin serum düzeylerinin düştüğü bildirilmiştir. Dolayısıyla bu azalma, lipid peroksidasyon ürünlerinin yansıttığı gibi, tamamen artan oksidatif strese bağlı değildir.
Wheezing andshortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show1 increased superoxide generation from leucocytesleukocytes,as well as increased lipid peroxidation product, indicatingboth of whichindicate increased oxidative stress. Ascorbic acid an important antioxidative 2directly neutralizes free radical, thus itis continuously utilizedused to maintain the a redoxstate oflung in the lungs of patients with 3asthma.Hatch et al.suggested that ascorbic acid is the major antioxidant substance present inthe airway surface liningliquid4 of the lung,and may protect against endogenous as well as exogenous oxidants. Our presentfinding thatof the low ascorbic acid causedlevel in children with5 wheezing in children couldmay be attributed toits normal physiological function, elevated utilization to overcome the continuousgeneration of oxidant radical and also and to neutralize theexogenous oxidant. It has been suggested that ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmaticairwaysairway inflammation. Our present findingsof lowascorbic acid levels in children with wheezingchildrenis are in agreement with the earlierreportsof, wherein researchers who attributedsuch kindof loweringthe decrease in the plasma ascorbicacid level inplasma to its normal physiological function i.e.,functions,including its utilizationroles in maintaining themaintenanceof body’s defense mechanism, tissue and in the integrity and,replacement and healing process. processes of tissues. 6Destructionof the respiratorymucous membrane during common cold and resulting reduction ofinthe tissueascorbic acid, level in the tissue 7mayfurther delay in the healing of the mucous membranesurface,leading to prolonged symptoms of asthma. A study shows that serum levels of antioxidantvitamins aredecreaseddecrease in the sera of asthmatic patientswithasthma, even during the asymptomatic periods of thedisease, and thus this decrease is not totally dependent on the increasedoxidative stress, as reflected by lipid peroxidationproducts.
Wheezing Bronchia asthma mainly manifests as wheezing 1and shortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show2 increased superoxide generation from leucocytesleukocytes, as well as and increased lipid peroxidation products, indicatingboth of which indicateincreased oxidative stress. Ascorbic acid is an important antioxidative 3that directly neutralizes free radicals; thustherefore,it is continuously usually 4utilizedused to maintain the a redoxstate of lung in the lungs of patients with 5asthma. According to Hatch et al. suggested that., ascorbic acidis the major antioxidant substance presentin the airway surface liningliquid6 of the lungs, and may protect against endogenous as well as and exogenousoxidants. Our present findingWe found that the presence of a that of the low ascorbic acid causedlevel in children with7 wheezing in children couldmay be attributed to its normal physiological function, and elevatedincreased utilization to overcome the continuous generation of oxidantradicals8 and also and9 to neutralize the exogenous oxidants.It has been suggested that Therefore10 ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmatic airways11airway inflammation. Our in patients with asthma. Consistent with our present findings of , other studies have also reported a low ascorbic acid levels in children with wheezing; children is are inagreement with the earlier reports of,wherein these researchers havewho attributedsuch kindof loweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological function i.e.,functions, including its in maintaining the utilizationrolesmaintenance of body’s defense mechanism,tissue and in the integrity and,replacement and healing process. 12processes of tissues. 13Destruction of the respiratorymucous membrane during common cold and resulting reduction the consequent decrease in tissue ascorbic acidofin, level14s in the tissue mayfurther delay in the healing of the mucous membrane surface,leadingand result in to prolonged asthma symptoms of asthma. A study shows that reported decreased serum levels of antioxidant vitamins are decreaseddecrease in the sera of asthmatic patients with asthma, even during the asymptomaticperiods of the disease, and thus.Therefore,15 this decrease is does not totally dependentcompletelydepend on the increased oxidative stress, as reflected bylipid peroxidation products.
Bronchial asthma mainly manifests as wheezing and shortness of breath. Patients with asthma show increased superoxide generation from leukocytes and increased lipid peroxidation products, both of which indicate increased oxidative stress. Ascorbic acid is an important antioxidant that directly neutralizes free radicals; therefore, it is usually used to maintain a redox state in the lungs of patients with asthma. According to Hatch et al., ascorbic acid is the major antioxidant in the airway surface liquid of the lungs and may protect against endogenous and exogenous oxidants. We found that the presence of a low ascorbic acid level in children with wheezing may be attributed to its normal physiological function and increased utilization to overcome the continuous generation of oxidant radicals and to neutralize exogenous oxidants. Therefore, ascorbic acid deficiency may be an underlying factor in the pathophysiology of asthma or a response to airway inflammation in patients with asthma. Consistent with our findings, other studies have also reported a low ascorbic acid level in children with wheezing; these researchers have attributed the decrease in the plasma ascorbic acid level to its normal physiological functions in maintaining the body’s defense mechanism and in the integrity, replacement, and healing processes of tissues. Destruction of the respiratory mucous membrane during common cold and the consequent decrease in tissue ascorbic acid levels may further delay the healing of the mucous membrane surface and result in prolonged asthma symptoms. A study reported decreased serum levels of antioxidant vitamins in patients with asthma, even during the asymptomatic period of the disease. Therefore, this decrease does not completely depend on increased oxidative stress, as reflected by lipid peroxidation products.
Çeviri süreci konu uzmanı tarafından Tercüman + çapraz kontrol
+ Anadil kontrolü
Uluslararası akademik dergilere başvuruda kullanılan makaleler (ör. Tez ya da tez özeti çevirisi...) ile çok büyük önem taşıyan belgeler.
Çeviri süreci konu uzmanı tarafından Tercüman +
Çapraz kontrol
Resmi, şirket içi iletişim belgeleri ve şirket dışı kullanılan belgeler
YAYINCI | DERGİ BİLGİLERİ | ETKİ FAKTÖRÜ | MAKALENİN BAŞLIĞI | YAZAR |
---|---|---|---|---|
The American Society of Hematology | Blood; February 16, 2011 | 10.56 | Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis | Sumegi Janos |
American Heart Association | Arteriosclerosis, Thrombosis, and Vascular Biology; 2009, 29:33-39 | 7.00 | Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice | Itabe Hiroyuki |
Blackwell Publishing Ltd | Alimentary Pharmacology and Therapeutics; Volume 28, Issue 10, Pages 1259–1264, November 2008 | 4.00 | The modified glucose clearance test: a novel non-invasive method for differentiating non-erosive reflux disease and erosive oesophagitis | Fujinami Haruka |
Enago editörleri tarafından düzenlenen makaleler, yüksek etki faktörlü ve SCI endeksli dergilerde yer almıştır. Aşağıda Enago müşterilerinin makalelerini gönderdikleri dergilerin listesini bulabilirsiniz